SCF

Recombinant Human SCF

Catalog Number : S001
Available Size : 10µg, 100µg, 500µg, 1mg
Synonyms : Stem Cell Factor, c-Kit Ligand, Mast Cell Growth Factor (MGF), Steel Factor
Description : SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. The human SCF gene encodes for a 273 amino acid transmembrane protein, which contains a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. The secreted soluble form of SCF is generated by proteolytic processing of the membrane anchored precursor. Recombinant Human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.
Source : INNOkine recombinant human SCF is produced in rice suspension cells (Oryza sativa L. cv. Dongjin)
Purity : Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level : <0.05 EU/µg
Biological Activity : The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Cross Reactivity : Monkey, Human, Mouse, Bacteria, Leech, Rat, Rabbit, Human + Mouse
Research Interests : Cell Culture, Immune System, Proliferation, Stem Cells & Differentiation
Research Use Only. Not for use in diagnostic or therapeutic procedures.
Animal-free
Mouse-free
Virus-free
Bacteria-free
Endotoxin-free