| Catalog Number : |
P001 |
| Available Size : |
10µg, 100µg, 500µg, 1mg |
| Synonyms : |
Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF) |
| Description : |
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two β chains (218 total amino acids). |
| Source : |
INNOkineⓇ recombinant human PDGFbb is produced in rice suspension cells (Oryza sativa L. cv. Dongjin) |
| Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
| Endotoxin Level : |
<0.05 EU/µg |
| Biological Activity : |
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells.The expected ED50 for this effect is 1.0-3.0 ng/ml. |
| Cross Reactivity : |
Cow, Monkey, Mouse, Pig, Rat, Human, Hamster, Leech |
| Research Interests : |
Angiogenesis / Cardiovascular, Bone, Skeletal, Cartilage, Cancer, Immune System, Neurobiology, Stem Cells & Differentiation, Wound healing |
| Research Use Only. Not for use in diagnostic or therapeutic procedures. |
