| Catalog Number : |
I002 |
| Available Size : |
10µg, 100µg, 500µg, 1mg |
| Synonyms : |
NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF |
| Description : |
IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues). |
| Source : |
INNOkineⓇrecombinant human IL-12 is produced in rice suspension cells (Oryza sativa L. cv. Dongjin) |
| Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
| Endotoxin Level : |
<0.05 EU/µg |
| Biological Activity : |
The ED50 was determined by the induction of IFN-γ from NK cells co-stimulated with IL-18 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. |
| Cross Reactivity : |
Bacteria, Monkey, Mouse, Human, Leech |
| Research Interests : |
Angiogenesis/Cardiovascular, Cancer, Immune System, Inflammation, Stem Cells & Differentiation, Allergy, Transplantation |
| Research Use Only. Not for use in diagnostic or therapeutic procedures. |
