| Catalog Number : |
H051 |
| Available Size : |
10µg, 100µg, 500µg, 1mg |
| Synonyms : |
Hepatocyte Growth Factor, Scatter Factor (SF), Hepatopoietin (HPTA) |
| Description : |
HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein containing 697 amino acid residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues. Recombinant Human HGF, sourced from rice cells, is a 79.4 kDa polypeptide consisting of 695 amino acid residues. As a result of glycosylation, Recombinant Human HGF migrates with an apparent molecular mass of approximately 68-85 kDa by SDS-PAGE gel, under non-reducing conditions. |
| Source : |
INNOkineⓇ recombinant human HGF is produced in rice suspension cells (Oryza sativa L. cv. Dongjin) |
| Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
| Endotoxin Level : |
<0.05EU/µg |
| Biological Activity : |
The ED50 was determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells was found to be in the range of 20.0-40.0 ng/ml. |
| Cross Reactivity : |
Dog, Monkey, Mouse, Rabbit, Rat, Human + Mouse, Human, Leech |
| Activity : |
Anti-Aging, Anti-Wrinkle, Anti-Hair Loss, Hair Growth |
| Research Interests : |
Angiogenesis / Cardiovascular, Cancer, Neurobiology, Proliferation, Stem Cells & Differentiation, Wound Healing |
| Research Use Only. Not for use in diagnostic or therapeutic procedures. |
