Recombinant Human FGF-basic
|Catalog Number :||F002|
|Available Size :||10µg, 100µg, 500µg, 1mg|
|Synonyms :||Fibroblast Growth Factor-basic, FGF-2, HBGF-2, Prostatropin|
|Description :||FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues.|
|Source :||INNOkineⓇ Human FGF-basic is produced in rice suspension cells (Oryza sativa L. cv. Dongjin)|
|Purity :||Greater than 98% by SDS-PAGE gel and HPLC analyses.|
|Endotoxin Level :||<0.05EU/µg|
|Biological Activity :||Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
|Cross Reactivity :||Cow, Dog, Frog, Hamster, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Human + Mouse, Rat + Chicken, Human, Horse, Bacteria, Trout, Chicken, Human + Rat, Leech, N/A, Human + Virus|
|Research Interests :||Angiogenesis/Cardiovascular, Cancer, Cell Culture, FGF Superfamily, Inflammation, Neurobiology, Proliferation, Stem cells & Differentiation, Wound Healing|
|Research Use Only. Not for use in diagnostic or therapeutic procedures.|